Veröffentlichungen und Patente:
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Jiahui Tao, Michael F. Jobling, Shyra J. Gardai, Carlos W. Bertoncini, Nunilo Cremades, Michael Bova, Stephen Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Nguyen, Mariano C. Tabios, Mitali A. Tambe, Jean-Christophe Rochet, Hans-Dieter Junker, Daniel Schwizer, Renate Sekul, Inge Ott, John P. Anderson, Balazs Szoke, Wherly Hoffman, John Christodoulou, Ted Yednock, David A. Agard, Dale Schenk, Lisa McConlogue. Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions. Scientific Reports 9 (1), 16947 (2019)
Tambe S, Blott H, Fülöp A, Spang N, Flottmann D, Bräse S, Hopf C, Junker HD. Structure-performance relationships of phenyl cinnamic acid derivatives as MALDI-MS matrices for sulfatide detection. Anal Bioanal Chem. 2017
Feb;409(6):1569-1580. doi: 10.1007/s00216-016-0096-6. Epub 2016 Dec 1. PubMed PMID: 27909779.
Fülöp A, Porada MB, Marsching C, Blott H, Meyer B, Tambe S, Sandhoff R, Junker HD, Hopf C. 4-Phenyl-α-cyanocinnamic acid amide: screening for a negative ion matrix for MALDI-MS imaging of multiple lipid classes. Anal Chem. 2013 Oct
1;85(19):9156-63. doi: 10.1021/ac4018154. Epub 2013 Sep 17. PubMed PMID: 23984824.
Heim-Riether A, Taylor SJ, Liang S, Gao DA, Xiong Z, Michael August E, Collins BK, Farmer BT 2nd, Haverty K, Hill-Drzewi M, Junker HD, Mariana Margarit S, Moss N, Neumann T, Proudfoot JR, Keenan LS, Sekul R, Zhang Q, Li J, Farrow NA. Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors. Bioorg Med Chem Lett. 2009
Neumann Th, Junker HD, Schmidt, K, Sekul R: SPR-based Fragment Screening: Advantages and Applications, Current Topics in Medicinal Chemistry, 2007,7(16), 1630-1642
Maier S, Frank M, Rau H, Lewandowski P, Uhrig R, Keil O, Deppe H, Müller N, Vanier C, Mannsperger H, Zepter S & Junker HD: Synthesis and Quality Control of Thiol Tagged Compound Libraries for Chemical Microarrays, Journal of QSAR and Combinatorial Sciences, 2006, 1047-1054
Neumann Th, Junker HD, Keil O, Burkert K, Ottleben O, Gamer J, Sekul R, Deppe H, Feurer A, Tomandl D, Metz G: Discovery of Thrombin Inhibitor Fragments from Chemical Microarray Screening, Letters in Drug Des.& Disc. 2005, 2, 590-594
Dickopf S, Frank M, Junker HD, Maier S, Metz G, Ottleben H, Rau H, Schellhaas N, Schmidt K, Sekul R, Vanier C, Vetter D, Czech J, Lorenz M, Matter H, Schudok M, Schreuder H, Will DW, Nestler HP: Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa, Analytical Biochemistry, 2004; 335(1):50-57
Uhrig R, Sekul R, Junker HD, Lawrence AM, Vogt S: Method and apparatus for etablishing ADME profiles in the early stage of development of active substances, EP 1439394 (2002), Graffinity Pharmaceuticals AG, Heidelberg
Junker HD, Hoehn ST, Bunt RC, Marathius V, Chen J, Turner CJ, Stubbe J: Synthesis, Characterization and Solution Structure of Tethered Oligonucleotides Containing an Internal 3'-Phospho-glycolate, 5'-Phosphate Gapped Lesion, Nucleic Acids Res. 30 (2002), 5497-5508
Hoehn ST, Junker HD, Bunt RC, Turner CJ, Stubbe J: Solution Structure of Co(III)-Bleomycin-OOH Bound to a Phospho-glycolate Lesion Containing Oligonucleotide: Implications for Bleomycin-Induced Double-Strand DNA Cleavage, Biochemistry, 40 (2001), 5894-5905
Junker HD, Phung N, Fessner WD: Diastereoselective Free Radical Synthesis of Alpha-Substituted C-Glycosyl-phosphonates, and their Use as Substrates in the HWE-Reaction, Tetrahedron Letters, 40 (1999), 7063-7067
Junker HD and Fessner WD: Diastereoselective Synthesis of C-Glycosylphosphonates via Free-Radical Glycosylation, Tetrahedron Letters, 39 (1998), 269-273
Junker HD: Synthese-Studien zu hydrolysestabilen Inhibitoren für Kohlenhydrat-prozessierende Enzyme, Dissertation, RWTH Aachen, 1998
Junker HD: Synthese und Assoziationsverhalten von Nucleosidderivaten, Diplomarbeit, Universität des Saarlandes, 1994
Konferenzbeiträge und Abstracts:
Junker HD, Tambe S, Blott H, Geissler D, "MALDI-MS Matrix Geometry is Decisive for Matrix-Analyte Selectivity " MSS II& OurCon VI Joint Meeting, Charleston, SC, USA, 11.-14.11.2018
Junker HD, Neumann T, Ott I, Maier S, Burkert K, Keil O, Schmidt K and Sekul R, “Fragment to lead evolution using chemical microarray screening”, 233rd ACS National Meeting, Chicago, IL, USA, 25-29.03.2007, Plenarvortrag
Junker HD, Neumann T, Ott I, Maier S, Burkert K, Keil O, Schmidt K and Sekul R, „Fragment evolution starting from surface plasmon imaging of chemical microarrays”, Gordon Research Conference Medicinal Chemistry 2006, New London, NH, USA, 6-11.08.2006, Poster-Abstract
Junker HD, Neumann T, Ott I, Maier S, Burkert K, Keil O, Schmidt K and Sekul R, „Fragment Discovery by Surface Plasmon Resonance Imaging“, P117, Cambridge Healthtech Institute`s Drug Discovery Chemistry 2006, Ja Jolla, USA, 23-26.04.2006, Poster-Abstract
Junker HD, Neumann T, Ott I, Maier S, Burkert K, Keil O, Schmidt K, and Sekul R, „Array Informed Fragment Discovery“, PCG 04, Jahrestagung der GDCh-Fachgruppe Medizinische Chemie, Frankfurt, 12.3.-15.3.2006, Poster-Abstract
Neumann T, Hill O, Burkert K, Junker HD, Otte K, Thiemann M, Sekul R, Gamer J and Schmidt K, „Fragment Screening on Chemical Microarrays using SPR Imaging Technology“, P02015, SBS 11th Annual Conference & Exhibition, Drug Discovery: From Targets to Candidates 11-15.9.2005 Geneva, Schweiz, Poster-Abstract
Neumann T, Gamer J, Burkert B, Keil O, Tomandl D, Metz G, Schmidt K, Maier S and Junker HD, “Chemical Microarrays-Tools for High Throughput Fragment Based Drug Discovery", Sci. Pharm. 73 (2005), Supplement 1, S48, Joint Meeting on Medicinal Chemistry, Wien, 20-23.06.2006 Kurzvortrag-Abstract
Junker HD, “High Throughput Fragment-Based Drug Discovery with Chemical Microarrays”, 2nd Anglo-Swedish Symposium on Medicinal Chemistry, Are, Schweden, 13.- 16.03.2005, Vortrag
Junker HD, Hoehn ST, Bunt RC, Turner CJ and Stubbe J
„Cobleomycin B2-green Bound to Oligonucleotides Containing Internal Phosphoglycolate Lesions: Insight into the Mechanism of Double-Stranded DNA Cleavage by Bleomycins“ Abstracts of papers of the american chemical society 219:U489-U489, 219th American Chemical Society National Meeting, San Francisco, USA 26-30.03.2000, Abstract-Kurzvortrag
Hoehn S, Junker HD, Kozarich J, Turner C, Stubbe J
„Bleomycins: Insights into Double-Stranded DNA Cleavage and Repair“, Abstracts of papers of the american chemical society 218: U1021-U1021, 218th American Chemical Society National Meeting, New Orleans, 22.-26.08.1999, Abstract
Junker HD and Fessner WD: "Synthesis of Tunicamycin Analogues by the HWE-Reaction", European Conference "Synthesis and Function of Bioactive Natural Products and Analogues", Goslar, 12.-15.06.1997, Poster-Abstract
Junker HD and Fessner WD: “Free Radical C-glycosylation by Glycosylphosphonates”, 3. Symposium des Sonderforschungs-bereiches 380 “Asymmetrische Synthese mit chemischen und biologischen Methoden”, Jülich, 7.11.1997, Poster-Abstract
